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Endogenous Depression – Genetic Ghost of Melancholia

Endogenous Depression

What Is Endogenous Depression

Endogenous depression is a category of depression that is said to be the result of neurotransmitter imbalance within the body. This may be the result of genetics or it may be a dysfunction within the body. It is most often prevalent because of the biological problem because there aren’t often external causes that bring the depression on.

Endogenous Depression: Symptoms, Cause, Treatment

If it is endogenous depression then medication is most often prescribed to the individual that is experiencing it. This type of anxiety comes from within, and although there have been various studies on this type of depression, scientists cannot come across any type of event that would trigger it.

Difference between reactive depression and endogenous depression

Depression is categorized in two ways, and it’s either reactive or it’s endogenous. When depression is reactive then is caused by something that happened, and the person will undergo redundancy. The word endogenous is also a term that is used to label certain patients who are not helped or affected by antidepressant medication.

Endogenous Depression Symptoms

Endogenous depression is called the 'genetic ghost of melancholia' because it will express symptoms that are similar to other types of depression but be suffered by it in a different way. A lot of anxious feelings, insomnia, weight gain or less, and low self-esteem may suddenly take over their behavior.

Unfortunately, some are born with a very severe form of this category and not all of those affected by it will experience similar symptoms.

It may be a more severe form of this type of depression if there is also another mental illness that is prevalent, and in the case of a separate prescription medicine. There are certain symptoms that are common when it is a severe endogenous depression:
  • the inability to concentrate,
  • forgetfulness,
  • negative thoughts,
  • a guilty conscience,
  • self-destruction thoughts,
  • crying without a reason to do so.
Patients may experience –
  • sexual problems,
  • antisocial thoughts,
  • bad hygiene, and
  • disinterest in leisurely activity and fatigue.
If you have experienced a combination of all of these symptoms then it’s recommended that you get help from a physician as soon as possible.

Causes of Endogenous Depression

This is a genetic mood disorder that is the result of very severe chemical balances within the brain and it most often cannot be fixed with mild therapy and meditation. When the amounts of neurotransmitters are increased in the body and communicate with the brain effectively then it will help the individual significantly.

This is a category of depression that can affect people of all ages and it may begin to reveal itself in the case of another illness or an accident. There may also be bodily pains if the depression is severe – if you are experiencing a depression that has suddenly hit you without an event or trigger then you may be experiencing endogenous depression.

Endogenous Depression Treatment

There are different ways to treat this problem and there are many medications available; it’s necessary that you adhere to all of the side effects that may come with the antidepressant medication.

Electroconvulsive therapy (ECT) may be used in cases when symptoms don’t improve with medication and therapy.


Making lifestyle changes can help relieve symptoms of endogenous depression, and make it easier to manage. Here are some lifestyle changes to consider:

1. Get regular exercise.

2. Eat a healthy diet.

3. Get enough sleep.

4. Limit your alcohol intake.

5. Connect with others.

Making these changes can be difficult, but they can make a big difference in your mental health. Talk to your doctor if you're struggling to make lifestyle changes on your own.

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