Psychotic Depression If a person is considered medically depressed and has a kind of psychosis , he could develop a condition described as psychotic depression ( Depression with Psychosis ). Psychosis is the condition wherein a person either has an indistinct view of reality or loses connection with reality. There are a lot of symptoms associated with psychotic depression. Although the depression symptoms are similar to those with people that experience clinical or mild depression, there are symptoms which are different to this type of depression. Psychotic Depression Causes There are many reasons for depression. It usually happens when a person goes through intense pain, fear and trauma. This may also be due to the hormonal changes in the body. Though there is no specific cause for psychotic depression, many studies show that one of the major causes is cortisol. When the cortisol level in the blood augments, it can have a deep effect on the brain of the sufferer and may lead to