There are a variety of treatment options for depression, and chances are you'll find one - or a combination - that works for you. Most Common and Effective Treatment for Depression Research studies do not predict individual responses to any specific depression treatment. In other words, just because a treatment works for some (or even most) people, doesn't mean it will work for you. It's important to keep this in mind if you or a loved one are undergoing treatment for depression, as the first treatment or series of treatments may not be effective. Depression is a complex illness. Most physicians practicing today believe that it is caused by a combination of biological (including genetic and bacterial), social, and psychological factors. A treatment approach that focuses solely on one of these factors is unlikely to be as beneficial as a treatment approach that includes both psychological and biological aspects (e.g., through psychotherapy and medication). So. what is the m...